AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53 signaling. Although 53BP1’s function is well established in DNA double-strand break repair, how its role in p53 signaling is modulated remains poorly understood. Here, we identify the scaffolding protein AHNAK as a G1 phase...

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Publicat a:Mol Cell
Autors principals: Ghodke, Indrajeet, Remisova, Michaela, Furst, Audrey, Kilic, Sinan, Reina-San-Martin, Bernardo, Poetsch, Anna R., Altmeyer, Matthias, Soutoglou, Evi
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221568/
https://ncbi.nlm.nih.gov/pubmed/33961796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.010
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