Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling

The interaction of the human FcγRIIA with immune complexes (ICs) promotes neutrophil activation and thus must be tightly controlled to avoid damage to healthy tissue. Here, we demonstrate that a fungal-derived soluble β-1,3/1,6-glucan binds to the glycosphingolipid long-chain lactosylceramide (LacCe...

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Vydáno v:Cell Rep
Hlavní autoři: Okubo, Koshu, Brenner, Michael D., Cullere, Xavier, Saggu, Gurpanna, Patchen, Myra L., Bose, Nandita, Mihori, Saki, Yuan, Zhou, Lowell, Clifford A., Zhu, Cheng, Mayadas, Tanya N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218468/
https://ncbi.nlm.nih.gov/pubmed/34010642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109142
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