Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

Vascular-deposited IgG immune complexes promote neutrophil recruitment, but how this process is regulated is still unclear. Here we show that the CD18 integrin Mac-1, in its bent state, interacts with the IgG receptor FcγRIIA in cis to reduce the affinity of FcγRIIA for IgG and inhibit FcγRIIA-media...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Saggu, Gurpanna, Okubo, Koshu, Chen, Yunfeng, Vattepu, Ravi, Tsuboi, Naotake, Rosetti, Florencia, Cullere, Xavier, Washburn, Nathaniel, Tahir, Suhail, Rosado, Aaron M., Holland, Steven M., Anthony, Robert M., Sen, Mehmet, Zhu, Cheng, Mayadas, Tanya N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265255/
https://ncbi.nlm.nih.gov/pubmed/30498196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07506-1
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