Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling

The interaction of the human FcγRIIA with immune complexes (ICs) promotes neutrophil activation and thus must be tightly controlled to avoid damage to healthy tissue. Here, we demonstrate that a fungal-derived soluble β-1,3/1,6-glucan binds to the glycosphingolipid long-chain lactosylceramide (LacCe...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Okubo, Koshu, Brenner, Michael D., Cullere, Xavier, Saggu, Gurpanna, Patchen, Myra L., Bose, Nandita, Mihori, Saki, Yuan, Zhou, Lowell, Clifford A., Zhu, Cheng, Mayadas, Tanya N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218468/
https://ncbi.nlm.nih.gov/pubmed/34010642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109142
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