Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo

Soluble immune complexes (ICs) are abundant in autoimmune diseases, yet neutrophil responses to these soluble humoral factors remain uncharacterized. Moreover, the individual role of the uniquely human FcγRIIA and glycophosphatidylinositol (GPI)–linked FcγRIIIB in IC-mediated inflammation is still d...

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Detalhes bibliográficos
Main Authors: Chen, Kan, Nishi, Hiroshi, Travers, Richard, Tsuboi, Naotake, Martinod, Kimberly, Wagner, Denisa D., Stan, Radu, Croce, Kevin, Mayadas, Tanya N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507149/
https://ncbi.nlm.nih.gov/pubmed/22955924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-401133
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