Functional Haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children

Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variation in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect differential binding of IgG sub-classes. Since variability in FcγR may play an impo...

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Main Authors: Ouma, Collins, Davenport, Gregory C., Garcia, Steven, Kempaiah, Prakasha, Chaudhary, Ateefa, Were, Tom, Anyona, Samuel B., Raballah, Evans, Konah, Stephen N., Hittner, James B., Vulule, John M., Ong’echa, John M., Perkins, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258363/
https://ncbi.nlm.nih.gov/pubmed/21818580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-011-1076-8
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