Reduced Systemic Bicyclo-Prostaglandin-E(2) and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia

In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E(2) (PGE(2)) through inducible cyclooxygenase-2 (COX-2) is an import...

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Bibliografiska uppgifter
I publikationen:Am J Hematol
Huvudupphovsmän: Anyona, Samuel B., Kempaiah, Prakasha, Raballah, Evans, Davenport, Gregory C., Were, Tom, Konah, Stephen N., Vulule, John M., Hittner, James B., Gichuki, Charity W., Ong’echa, John M., Perkins, Douglas J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703400/
https://ncbi.nlm.nih.gov/pubmed/22730036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23253
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