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Reduced Systemic Bicyclo-Prostaglandin-E(2) and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia

In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E(2) (PGE(2)) through inducible cyclooxygenase-2 (COX-2) is an import...

詳細記述

保存先:
書誌詳細
出版年:Am J Hematol
主要な著者: Anyona, Samuel B., Kempaiah, Prakasha, Raballah, Evans, Davenport, Gregory C., Were, Tom, Konah, Stephen N., Vulule, John M., Hittner, James B., Gichuki, Charity W., Ong’echa, John M., Perkins, Douglas J.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703400/
https://ncbi.nlm.nih.gov/pubmed/22730036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23253
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