Reduced Systemic Bicyclo-Prostaglandin-E(2) and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia

In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E(2) (PGE(2)) through inducible cyclooxygenase-2 (COX-2) is an import...

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發表在:Am J Hematol
Main Authors: Anyona, Samuel B., Kempaiah, Prakasha, Raballah, Evans, Davenport, Gregory C., Were, Tom, Konah, Stephen N., Vulule, John M., Hittner, James B., Gichuki, Charity W., Ong’echa, John M., Perkins, Douglas J.
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703400/
https://ncbi.nlm.nih.gov/pubmed/22730036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.23253
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