Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

The transcription factor Glioma-Associated Oncogene Homolog 1 (GLI1) is activated by sonic hedgehog (SHH) cascade and is an established driver of pancreatic ductal adenocarcinoma (PDAC). However, therapies targeting upstream hedgehog signaling have shown little to no efficacy in clinical trials. Her...

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Опубликовано в: :Cancer Lett
Главные авторы: Viswakarma, Navin, Sondarva, Gautam, Principe, Daniel R., Nair, Rakesh Sathish, Kumar, Sandeep, Singh, Sunil Kumar, Das, Subhasis, Sinha, Subhash C., Grippo, Paul J, Grimaldo, Sam, Giulianotti, Pier Cristoforo, Rana, Basabi, Rana, Ajay
Формат: Artigo
Язык:Inglês
Опубликовано: 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215900/
https://ncbi.nlm.nih.gov/pubmed/34052323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2021.04.015
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