Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival

Human epidermal growth factor receptor 2 (HER2) is amplified in ∼15–20% of human breast cancer and is important for tumor etiology and therapeutic options of breast cancer. Up-regulation of HER2 oncogene initiates cascades of events cumulating to the stimulation of transforming PI3K/AKT signaling, w...

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Vydáno v:J Biol Chem
Hlavní autoři: Das, Subhasis, Sondarva, Gautam, Viswakarma, Navin, Nair, Rakesh Sathish, Osipo, Clodia, Tzivion, Guri, Rana, Basabi, Rana, Ajay
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571892/
https://ncbi.nlm.nih.gov/pubmed/26152725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655563
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