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Mixed Lineage Kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-Activated Kinase 1
Mixed Lineage Kinase 3 (MLK3), a MAP3K member has been envisioned as a viable drug target in cancer, yet its detailed function and signaling is not fully elucidated. We identified that MLK3 tightly associates with an oncogene, PAK1. Mammalian PAK1 being a Ste20 (MAP4K) member, we tested whether it i...
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| Publicat a: | Oncogene |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7568686/ https://ncbi.nlm.nih.gov/pubmed/30664689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0690-0 |
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