Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8(+) T cells

BACKGROUND: The mitogen-activated protein kinases (MAPKs) are important for T cell survival and their effector function. Mixed lineage kinase 3 (MLK3) (MAP3K11) is an upstream regulator of MAP kinases and emerging as a potential candidate for targeted cancer therapy; yet, its role in T cell survival...

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Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Kumar, Sandeep, Singh, Sunil Kumar, Viswakarma, Navin, Sondarva, Gautam, Nair, Rakesh Sathish, Sethupathi, Periannan, Dorman, Matthew, Sinha, Subhash C, Hoskins, Kent, Thatcher, Gregory, Rana, Basabi, Rana, Ajay
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2020
Sujets:
Clinical/Translational Cancer Immunotherapy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410077/
https://ncbi.nlm.nih.gov/pubmed/32759234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000494
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