Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity

Mixed lineage kinase 3 (MLK3), also known as MAP3K11, was initially identified in a megakaryocytic cell line and is an emerging therapeutic target in cancer, yet its role in immune cells is not known. Here, we report that loss or pharmacological inhibition of MLK3 promotes activation and cytotoxicit...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kumar, Sandeep, Singh, Sunil Kumar, Viswakarma, Navin, Sondarva, Gautam, Nair, Rakesh Sathish, Sethupathi, Periannan, Sinha, Subhash C., Emmadi, Rajyasree, Hoskins, Kent, Danciu, Oana, Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149389/
https://ncbi.nlm.nih.gov/pubmed/32209667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921325117
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