Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity

Mixed lineage kinase 3 (MLK3), also known as MAP3K11, was initially identified in a megakaryocytic cell line and is an emerging therapeutic target in cancer, yet its role in immune cells is not known. Here, we report that loss or pharmacological inhibition of MLK3 promotes activation and cytotoxicit...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kumar, Sandeep, Singh, Sunil Kumar, Viswakarma, Navin, Sondarva, Gautam, Nair, Rakesh Sathish, Sethupathi, Periannan, Sinha, Subhash C., Emmadi, Rajyasree, Hoskins, Kent, Danciu, Oana, Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149389/
https://ncbi.nlm.nih.gov/pubmed/32209667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921325117
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