Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity

Mixed lineage kinase 3 (MLK3), also known as MAP3K11, was initially identified in a megakaryocytic cell line and is an emerging therapeutic target in cancer, yet its role in immune cells is not known. Here, we report that loss or pharmacological inhibition of MLK3 promotes activation and cytotoxicit...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kumar, Sandeep, Singh, Sunil Kumar, Viswakarma, Navin, Sondarva, Gautam, Nair, Rakesh Sathish, Sethupathi, Periannan, Sinha, Subhash C., Emmadi, Rajyasree, Hoskins, Kent, Danciu, Oana, Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149389/
https://ncbi.nlm.nih.gov/pubmed/32209667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921325117
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