Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

The transcription factor Glioma-Associated Oncogene Homolog 1 (GLI1) is activated by sonic hedgehog (SHH) cascade and is an established driver of pancreatic ductal adenocarcinoma (PDAC). However, therapies targeting upstream hedgehog signaling have shown little to no efficacy in clinical trials. Her...

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Publicado en:Cancer Lett
Main Authors: Viswakarma, Navin, Sondarva, Gautam, Principe, Daniel R., Nair, Rakesh Sathish, Kumar, Sandeep, Singh, Sunil Kumar, Das, Subhasis, Sinha, Subhash C., Grippo, Paul J, Grimaldo, Sam, Giulianotti, Pier Cristoforo, Rana, Basabi, Rana, Ajay
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215900/
https://ncbi.nlm.nih.gov/pubmed/34052323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2021.04.015
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