Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

The transcription factor Glioma-Associated Oncogene Homolog 1 (GLI1) is activated by sonic hedgehog (SHH) cascade and is an established driver of pancreatic ductal adenocarcinoma (PDAC). However, therapies targeting upstream hedgehog signaling have shown little to no efficacy in clinical trials. Her...

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Bibliografski detalji
Izdano u:Cancer Lett
Glavni autori: Viswakarma, Navin, Sondarva, Gautam, Principe, Daniel R., Nair, Rakesh Sathish, Kumar, Sandeep, Singh, Sunil Kumar, Das, Subhasis, Sinha, Subhash C., Grippo, Paul J, Grimaldo, Sam, Giulianotti, Pier Cristoforo, Rana, Basabi, Rana, Ajay
Format: Artigo
Jezik:Inglês
Izdano: 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215900/
https://ncbi.nlm.nih.gov/pubmed/34052323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2021.04.015
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