Mixed Lineage Kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-Activated Kinase 1

Mixed Lineage Kinase 3 (MLK3), a MAP3K member has been envisioned as a viable drug target in cancer, yet its detailed function and signaling is not fully elucidated. We identified that MLK3 tightly associates with an oncogene, PAK1. Mammalian PAK1 being a Ste20 (MAP4K) member, we tested whether it i...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Das, Subhasis, Nair, Rakesh Sathish, Mishra, Rajakishore, Sondarva, Gautam, Viswakarma, Navin, Abdelkarim, Hazem, Gaponenko, Vadim, Rana, Basabi, Rana, Ajay
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568686/
https://ncbi.nlm.nih.gov/pubmed/30664689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0690-0
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