Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads

Immunotherapies are a promising advance in cancer treatment. However, because only a subset of cancer patients benefits from these treatments it is important to find mechanisms that will broaden the responding patient population. Generally, tumors with high mutational burdens have the potential to e...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lussier, Danielle M., Alspach, Elise, Ward, Jeffrey P., Miceli, Alexander P., Runci, Daniele, White, J. Michael, Mpoy, Cedric, Arthur, Cora D., Kohlmiller, Heather N., Jacks, Tyler, Artyomov, Maxim N., Rogers, Buck E., Schreiber, Robert D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214694/
https://ncbi.nlm.nih.gov/pubmed/34099555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2102611118
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