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RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation
Ryanodine receptors (RyRs) are ion channels that mediate the release of Ca(2+) from the sarcoplasmic reticulum/endoplasmic reticulum, mutations of which are implicated in a number of human diseases. The adjacent C-terminal domains (CTDs) of cardiac RyR (RyR2) interact with each other to form a ring-...
Tallennettuna:
| Julkaisussa: | J Biol Chem |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2021
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8214192/ https://ncbi.nlm.nih.gov/pubmed/34022226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100808 |
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