RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation

Ryanodine receptors (RyRs) are ion channels that mediate the release of Ca(2+) from the sarcoplasmic reticulum/endoplasmic reticulum, mutations of which are implicated in a number of human diseases. The adjacent C-terminal domains (CTDs) of cardiac RyR (RyR2) interact with each other to form a ring-...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Guo, Wenting, Wei, Jinhong, Estillore, John Paul, Zhang, Lin, Wang, Ruiwu, Sun, Bo, Chen, S. R. Wayne
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214192/
https://ncbi.nlm.nih.gov/pubmed/34022226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100808
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