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The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability
Structural analyses identified the central domain of ryanodine receptor (RyR) as a transducer converting conformational changes in the cytoplasmic platform to the RyR gate. The central domain is also a regulatory hub encompassing the Ca(2+)-, ATP-, and caffeine-binding sites. However, the role of th...
Guardat en:
| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7667974/ https://ncbi.nlm.nih.gov/pubmed/32878990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013512 |
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