Enhanced Cytosolic Ca(2+) Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias

Recent three-dimensional structural studies reveal that the central domain of ryanodine receptor (RyR) serves as a transducer that converts long-range conformational changes into the gating of the channel pore. Interestingly, the central domain encompasses one of the mutation hotspots (corresponding...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Xiao, Zhichao, Guo, Wenting, Sun, Bo, Hunt, Donald J., Wei, Jinhong, Liu, Yingjie, Wang, Yundi, Wang, Ruiwu, Jones, Peter P., Back, Thomas G., Chen, S. R. Wayne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114406/
https://ncbi.nlm.nih.gov/pubmed/27733687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756528
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