The EF-hand Ca(2+) Binding Domain Is Not Required for Cytosolic Ca(2+) Activation of the Cardiac Ryanodine Receptor

Activation of the cardiac ryanodine receptor (RyR2) by elevating cytosolic Ca(2+) is a central step in the process of Ca(2+)-induced Ca(2+) release, but the molecular basis of RyR2 activation by cytosolic Ca(2+) is poorly defined. It has been proposed recently that the putative Ca(2+) binding domain...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Guo, Wenting, Sun, Bo, Xiao, Zhichao, Liu, Yingjie, Wang, Yundi, Zhang, Lin, Wang, Ruiwu, Chen, S. R. Wayne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732201/
https://ncbi.nlm.nih.gov/pubmed/26663082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.693325
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