SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

The SWI/SNF chromatin remodeling complex regulates transcription through the control of chromatin structure and is increasingly thought to play an important role in human cancer. Lung adenocarcinoma (LADC) patients frequently harbor mutations in SMARCA4, a core component of this multisubunit complex...

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Bibliografiska uppgifter
I publikationen:NAR Cancer
Huvudupphovsmän: Kurashima, Kiminori, Kashiwagi, Hideto, Shimomura, Iwao, Suzuki, Ayako, Takeshita, Fumitaka, Mazevet, Marianne, Harata, Masahiko, Yamashita, Takayuki, Yamamoto, Yusuke, Kohno, Takashi, Shiotani, Bunsyo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
DNA Damage Sensing and Repair
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210217/
https://ncbi.nlm.nih.gov/pubmed/34316685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa005
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