SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

The SWI/SNF chromatin remodeling complex regulates transcription through the control of chromatin structure and is increasingly thought to play an important role in human cancer. Lung adenocarcinoma (LADC) patients frequently harbor mutations in SMARCA4, a core component of this multisubunit complex...

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Foilsithe in:NAR Cancer
Main Authors: Kurashima, Kiminori, Kashiwagi, Hideto, Shimomura, Iwao, Suzuki, Ayako, Takeshita, Fumitaka, Mazevet, Marianne, Harata, Masahiko, Yamashita, Takayuki, Yamamoto, Yusuke, Kohno, Takashi, Shiotani, Bunsyo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
DNA Damage Sensing and Repair
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210217/
https://ncbi.nlm.nih.gov/pubmed/34316685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa005
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