SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

The SWI/SNF chromatin remodeling complex regulates transcription through the control of chromatin structure and is increasingly thought to play an important role in human cancer. Lung adenocarcinoma (LADC) patients frequently harbor mutations in SMARCA4, a core component of this multisubunit complex...

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Detaylı Bibliyografya
Yayımlandı:NAR Cancer
Asıl Yazarlar: Kurashima, Kiminori, Kashiwagi, Hideto, Shimomura, Iwao, Suzuki, Ayako, Takeshita, Fumitaka, Mazevet, Marianne, Harata, Masahiko, Yamashita, Takayuki, Yamamoto, Yusuke, Kohno, Takashi, Shiotani, Bunsyo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
DNA Damage Sensing and Repair
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210217/
https://ncbi.nlm.nih.gov/pubmed/34316685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa005
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