SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

The SWI/SNF chromatin remodeling complex regulates transcription through the control of chromatin structure and is increasingly thought to play an important role in human cancer. Lung adenocarcinoma (LADC) patients frequently harbor mutations in SMARCA4, a core component of this multisubunit complex...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:NAR Cancer
Egile Nagusiak: Kurashima, Kiminori, Kashiwagi, Hideto, Shimomura, Iwao, Suzuki, Ayako, Takeshita, Fumitaka, Mazevet, Marianne, Harata, Masahiko, Yamashita, Takayuki, Yamamoto, Yusuke, Kohno, Takashi, Shiotani, Bunsyo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
DNA Damage Sensing and Repair
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210217/
https://ncbi.nlm.nih.gov/pubmed/34316685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa005
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