Selinexor in combination with R-CHOP for frontline treatment of non-Hodgkin lymphoma: results of a phase 1 study

BACKGROUND: The nuclear exporter protein exportin-1 (XPO1) is overexpressed in non-Hodgkin’s lymphoma (NHL) and correlates with poor prognosis. We evaluated enhancing R-CHOP activity in NHL by targeted inhibition of XPO1 using the Selective Inhibitor of Nuclear Export (SINE) compounds, selinexor and...

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Publicado en:Clin Cancer Res
Main Authors: Seymour, Erlene K., Yar Khan, Husain, li, Yiwei, Chaker, Mahmoud, Muqbil, Irfana, Aboukameel, Amro, Ramchandren, Radhakrishanan, Houde, Christiane, Sterbis, Golbon, Yang, Jay, Bhutani, Divaya, Pregja, Silvana, Reichel, Kathy, Huddlestun, Amy, Neveux, Colleen, Corona, Kelly, Landsman, Yosef, Shah, Jatin, Kauffman, Michael, Shacham, Sharon, Mohammad, Ramzi M., Azmi, Asfar S., Zonder, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197746/
https://ncbi.nlm.nih.gov/pubmed/33785483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4929
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