Pre-clinical anti-tumor activity of Bruton's Tyrosine Kinase inhibitor in Hodgkin's Lymphoma cellular and subcutaneous tumor model

Bruton's Tyrosine Kinase (BTK) is a member of the TEC family and plays a central role in B-cell signaling, activation, proliferation and differentiation. Here we evaluated the impact of BTK inhibitor Ibrutinib on a panel of HL models in vitro and in vivo. Ibrutinib suppressed viability and indu...

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Bibliografiske detaljer
Udgivet i:Heliyon
Main Authors: Muqbil, Irfana, Chaker, Mahmoud, Aboukameel, Amro, Mohammad, Ramzi M., Azmi, Asfar S., Ramchandren, Radhakrishanan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726720/
https://ncbi.nlm.nih.gov/pubmed/31508518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2019.e02290
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