Selinexor in combination with R-CHOP for frontline treatment of non-Hodgkin lymphoma: results of a phase 1 study

BACKGROUND: The nuclear exporter protein exportin-1 (XPO1) is overexpressed in non-Hodgkin’s lymphoma (NHL) and correlates with poor prognosis. We evaluated enhancing R-CHOP activity in NHL by targeted inhibition of XPO1 using the Selective Inhibitor of Nuclear Export (SINE) compounds, selinexor and...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Seymour, Erlene K., Yar Khan, Husain, li, Yiwei, Chaker, Mahmoud, Muqbil, Irfana, Aboukameel, Amro, Ramchandren, Radhakrishanan, Houde, Christiane, Sterbis, Golbon, Yang, Jay, Bhutani, Divaya, Pregja, Silvana, Reichel, Kathy, Huddlestun, Amy, Neveux, Colleen, Corona, Kelly, Landsman, Yosef, Shah, Jatin, Kauffman, Michael, Shacham, Sharon, Mohammad, Ramzi M., Azmi, Asfar S., Zonder, Jeffrey A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197746/
https://ncbi.nlm.nih.gov/pubmed/33785483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4929
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak