Selinexor in combination with R-CHOP for frontline treatment of non-Hodgkin lymphoma: results of a phase 1 study

BACKGROUND: The nuclear exporter protein exportin-1 (XPO1) is overexpressed in non-Hodgkin’s lymphoma (NHL) and correlates with poor prognosis. We evaluated enhancing R-CHOP activity in NHL by targeted inhibition of XPO1 using the Selective Inhibitor of Nuclear Export (SINE) compounds, selinexor and...

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Pubblicato in:Clin Cancer Res
Autori principali: Seymour, Erlene K., Yar Khan, Husain, li, Yiwei, Chaker, Mahmoud, Muqbil, Irfana, Aboukameel, Amro, Ramchandren, Radhakrishanan, Houde, Christiane, Sterbis, Golbon, Yang, Jay, Bhutani, Divaya, Pregja, Silvana, Reichel, Kathy, Huddlestun, Amy, Neveux, Colleen, Corona, Kelly, Landsman, Yosef, Shah, Jatin, Kauffman, Michael, Shacham, Sharon, Mohammad, Ramzi M., Azmi, Asfar S., Zonder, Jeffrey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8197746/
https://ncbi.nlm.nih.gov/pubmed/33785483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4929
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