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Selinexor in combination with R-CHOP for frontline treatment of non-Hodgkin lymphoma: results of a phase 1 study
BACKGROUND: The nuclear exporter protein exportin-1 (XPO1) is overexpressed in non-Hodgkin’s lymphoma (NHL) and correlates with poor prognosis. We evaluated enhancing R-CHOP activity in NHL by targeted inhibition of XPO1 using the Selective Inhibitor of Nuclear Export (SINE) compounds, selinexor and...
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| Udgivet i: | Clin Cancer Res |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8197746/ https://ncbi.nlm.nih.gov/pubmed/33785483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4929 |
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