The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53

Amplification of MYCN is a poor prognostic feature in neuroblastoma (NBL) indicating aggressive disease. We and others have shown BET bromodomain inhibitors (BETi) target MYCN indirectly by downregulating its transcription. Here we sought to identify agents that synergize with BETi and to identify b...

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Vydáno v:Neoplasia
Hlavní autoři: Yi, Joanna S., Sias-Garcia, Oscar, Nasholm, Nicole, Hu, Xiaoyu, Iniguez, Amanda Balboni, Hall, Matthew D., Davis, Mindy, Guha, Rajarshi, Moreno-Smith, Myrthala, Barbieri, Eveline, Duong, Kevin, Koach, Jessica, Qi, Jun, Bradner, James E., Stegmaier, Kimberly, Weiss, William A., Gustafson, W. Clay
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192452/
https://ncbi.nlm.nih.gov/pubmed/34107377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2021.05.003
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