BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Patients usually undergo surgery followed by aggressive radio- and chemotherapy with the alkylating agent temozolomide (TMZ). Still, median survival is only 12–15 months after diagnosis. Many human cancers incl...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Čančer, Matko, Drews, Lisa F., Bengtsson, Johan, Bolin, Sara, Rosén, Gabriela, Westermark, Bengt, Nelander, Sven, Forsberg-Nilsson, Karin, Uhrbom, Lene, Weishaupt, Holger, Swartling, Fredrik J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872649/
https://ncbi.nlm.nih.gov/pubmed/31754113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2120-1
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