The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ

Iron-sulfur clusters (4Fe–4S) exist in many enzymes concerned with DNA replication and repair. The contribution of these clusters to enzymatic activity is not fully understood. We identified the MET18 (MMS19) gene of Saccharomyces cerevisiae as a strong mutator on GC-rich genes. Met18p is required f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Kiktev, Denis A, Dominska, Margaret, Zhang, Tony, Dahl, Joseph, Stepchenkova, Elena I, Mieczkowski, Piotr, Burgers, Peter M, Lujan, Scott, Burkholder, Adam, Kunkel, Thomas A, Petes, Thomas D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2021
Pynciau:
Genome Integrity, Repair and Replication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191807/
https://ncbi.nlm.nih.gov/pubmed/34019669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab371
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