DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation

Previous evidence indicates that telomeres resemble common fragile sites and present a challenge for DNA replication. The precise impediments to replication fork progression at telomeric TTAGGG repeats are unknown, but are proposed to include G-quadruplexes (G4) on the G-rich strand. Here we examine...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lormand, Justin D., Buncher, Noah, Murphy, Connor T., Kaur, Parminder, Lee, Marietta Y., Burgers, Peter, Wang, Hong, Kunkel, Thomas A., Opresko, Patricia L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905856/
https://ncbi.nlm.nih.gov/pubmed/24038470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt813
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