Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures

Pif1 DNA helicase is a potent unwinder of G-quadruplex (G4) structures in vitro and functions to maintain genome stability at G4 sequences in Saccharomyces cerevisiae. Here, we developed and utilized a live-cell imaging approach to quantitatively measure the progression rates of single replication f...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Dahan, Danielle, Tsirkas, Ioannis, Dovrat, Daniel, Sparks, Melanie A, Singh, Saurabh P, Galletto, Roberto, Aharoni, Amir
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294490/
https://ncbi.nlm.nih.gov/pubmed/30395308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1065
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