The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity

Pif1 family DNA helicases are conserved from bacteria to humans and have critical and diverse functions in vivo that promote genome integrity. Pif1 family helicases share a 23 amino acid region, called the Pif1 signature motif (SM) that is unique to this family. To determine the importance of the SM...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Geronimo, Carly L, Singh, Saurabh P, Galletto, Roberto, Zakian, Virginia A
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144861/
https://ncbi.nlm.nih.gov/pubmed/30239884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky655
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