Loop 1 modulates the fidelity of DNA polymerase λ

Differences in the substrate specificity of mammalian family X DNA polymerases are proposed to partly depend on a loop (loop 1) upstream of the polymerase active site. To examine if this is the case in DNA polymerase λ (pol λ), here we characterize a variant of the human polymerase in which nine res...

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Bibliographische Detailangaben
Hauptverfasser: Bebenek, Katarzyna, Garcia-Diaz, Miguel, Zhou, Rui-Zhe, Povirk, Lawrence F., Kunkel, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938210/
https://ncbi.nlm.nih.gov/pubmed/20435673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq261
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