The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity

The four B-family DNA polymerases α, δ, ϵ and ζ cooperate to accurately replicate the eukaryotic nuclear genome. Here, we report that a Saccharomyces cerevisiae strain encoding the pol2-16 mutation that lacks Pol ϵ’s polymerase and exonuclease activities has increased dNTP concentrations and an incr...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Garbacz, Marta A, Cox, Phillip B, Sharma, Sushma, Lujan, Scott A, Chabes, Andrei, Kunkel, Thomas A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486559/
https://ncbi.nlm.nih.gov/pubmed/30698744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz048
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