Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase λ in human nuclear extracts

Ionizing radiation induces various clustered DNA lesions, including double-strand breaks (DSBs) accompanied by nearby oxidative base damage. Previous work showed that, in HeLa nuclear extracts, DSBs with partially complementary 3′ overhangs and a one-base gap in each strand are accurately rejoined,...

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Hlavní autoři: Zhou, Rui-Zhe, Blanco, Luis, Garcia-Diaz, Miguel, Bebenek, Katarzyna, Kunkel, Thomas A., Povirk, Lawrence F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396438/
https://ncbi.nlm.nih.gov/pubmed/18385158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn126
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