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A tripartite mechanism catalyzes Mad2–Cdc20 assembly at unattached kinetochores
During cell division, kinetochores couple chromosomes to spindle microtubules. To protect against chromosome gain or loss, kinetochores lacking microtubule attachment locally catalyze association of the checkpoint proteins Cdc20 and Mad2, which is the key event in the formation of a diffusible check...
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| Vydáno v: | Science |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8191211/ https://ncbi.nlm.nih.gov/pubmed/33384372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc1424 |
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