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Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

Premature anaphase onset is prevented by the mitotic checkpoint through production of a “wait anaphase” inhibitor(s) that blocks recognition of cyclin B and securin by Cdc20-activated APC/C, an E3 ubiquitin ligase which targets them for destruction. Using physiologically-relevant levels of Mad2, Bub...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kulukian, Anita, Han, Joo Seok, Cleveland, Don W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655205/
https://ncbi.nlm.nih.gov/pubmed/19154722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.11.005
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