Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by Mad2-induced Functional Switch in Cdc20

The mitotic checkpoint acts to maintain chromosome content by generation of a diffusible anaphase inhibitor. Unattached kinetochores catalyze a conformational shift in Mad2, converting an inactive open form into a closed one that can capture Cdc20, the mitotic activator of the APC/C ubiquitin ligase...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Han, Joo Seok, Holland, Andrew J., Fachinetti, Daniele, Kulukian, Anita, Cetin, Bulent, Cleveland, Don W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713096/
https://ncbi.nlm.nih.gov/pubmed/23791783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.019
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky