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Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by Mad2-induced Functional Switch in Cdc20
The mitotic checkpoint acts to maintain chromosome content by generation of a diffusible anaphase inhibitor. Unattached kinetochores catalyze a conformational shift in Mad2, converting an inactive open form into a closed one that can capture Cdc20, the mitotic activator of the APC/C ubiquitin ligase...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3713096/ https://ncbi.nlm.nih.gov/pubmed/23791783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.019 |
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