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Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling

The mitotic checkpoint (also known as the spindle assembly checkpoint) prevents premature anaphase onset through generation of an inhibitor of the E3 ubiquitin ligase APC/C, whose ubiquitination of cyclin B and securin targets them for degradation. Combining in vitro reconstitution and cell-based as...

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Detalhes bibliográficos
Main Authors: Han, Joo Seok, Vitre, Benjamin, Fachinetti, Daniele, Cleveland, Don W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210015/
https://ncbi.nlm.nih.gov/pubmed/25246557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416277111
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