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Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling
The mitotic checkpoint (also known as the spindle assembly checkpoint) prevents premature anaphase onset through generation of an inhibitor of the E3 ubiquitin ligase APC/C, whose ubiquitination of cyclin B and securin targets them for degradation. Combining in vitro reconstitution and cell-based as...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210015/ https://ncbi.nlm.nih.gov/pubmed/25246557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416277111 |
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