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A tripartite mechanism catalyzes Mad2–Cdc20 assembly at unattached kinetochores

During cell division, kinetochores couple chromosomes to spindle microtubules. To protect against chromosome gain or loss, kinetochores lacking microtubule attachment locally catalyze association of the checkpoint proteins Cdc20 and Mad2, which is the key event in the formation of a diffusible check...

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Publicado en:Science
Main Authors: Lara-Gonzalez, Pablo, Kim, Taekyung, Oegema, Karen, Corbett, Kevin, Desai, Arshad
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191211/
https://ncbi.nlm.nih.gov/pubmed/33384372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc1424
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