Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Interferons can diminish HBV cccDNA via APOBEC3‐mediated deamination. Here, we show that overexpression of APOBEC3A alone is not...

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Bibliografiska uppgifter
I publikationen:EMBO Rep
Huvudupphovsmän: Stadler, Daniela, Kächele, Martin, Jones, Alisha N, Hess, Julia, Urban, Christian, Schneider, Jessica, Xia, Yuchen, Oswald, Andreas, Nebioglu, Firat, Bester, Romina, Lasitschka, Felix, Ringelhan, Marc, Ko, Chunkyu, Chou, Wen‐Min, Geerlof, Arie, van de Klundert, Maarten A, Wettengel, Jochen M, Schirmacher, Peter, Heikenwälder, Mathias, Schreiner, Sabrina, Bartenschlager, Ralf, Pichlmair, Andreas, Sattler, Michael, Unger, Kristian, Protzer, Ulrike
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2021
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183418/
https://ncbi.nlm.nih.gov/pubmed/33969602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949568
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