Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

Current antivirals can control but not eliminate hepatitis-B-virus (HBV), because HBV establishes a stable nuclear cccDNA. Interferon-α treatment can clear HBV but is limited by systemic side effects. Here we describe how interferon-α can induce specific degradation of the nuclear viral DNA without...

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Pubblicato in:Science
Autori principali: Lucifora, Julie, Xia, Yuchen, Reisinger, Florian, Zhang, Ke, Stadler, Daniela, Cheng, Xiaoming, Sprinzl, Martin F., Koppensteiner, Herwig, Makowska, Zuzanna, Volz, Tassilo, Remouchamps, Caroline, Chou, Wen-Min, Thasler, Wolfgang E., Hüser, Norbert, Durantel, David, Liang, T. Jake, Münk, Carsten, Heim, Markus H., Browning, Jeffrey L., Dejardin, Emmanuel, Dandri, Maura, Schindler, Michael, Heikenwalder, Mathias, Protzer, Ulrike
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309542/
https://ncbi.nlm.nih.gov/pubmed/24557838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243462
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