Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Interferons can diminish HBV cccDNA via APOBEC3‐mediated deamination. Here, we show that overexpression of APOBEC3A alone is not...

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Udgivet i:EMBO Rep
Main Authors: Stadler, Daniela, Kächele, Martin, Jones, Alisha N, Hess, Julia, Urban, Christian, Schneider, Jessica, Xia, Yuchen, Oswald, Andreas, Nebioglu, Firat, Bester, Romina, Lasitschka, Felix, Ringelhan, Marc, Ko, Chunkyu, Chou, Wen‐Min, Geerlof, Arie, van de Klundert, Maarten A, Wettengel, Jochen M, Schirmacher, Peter, Heikenwälder, Mathias, Schreiner, Sabrina, Bartenschlager, Ralf, Pichlmair, Andreas, Sattler, Michael, Unger, Kristian, Protzer, Ulrike
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8183418/
https://ncbi.nlm.nih.gov/pubmed/33969602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949568
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