Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

BACKGROUND & AIMS: Several steps in the HBV life cycle remain obscure because of a lack of robust in vitro infection models. These steps include particle entry, formation and maintenance of covalently closed circular (ccc) DNA, kinetics of gene expression and viral transmission routes. This stud...

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Vydáno v:J Hepatol
Hlavní autoři: Ko, Chunkyu, Chakraborty, Anindita, Chou, Wen-Min, Hasreiter, Julia, Wettengel, Jochen M., Stadler, Daniela, Bester, Romina, Asen, Theresa, Zhang, Ke, Wisskirchen, Karin, McKeating, Jane A., Ryu, Wang-Shick, Protzer, Ulrike
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611400/
https://ncbi.nlm.nih.gov/pubmed/30142426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2018.08.012
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