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Mitochondrial Bioenergetics Profile With Different Mechanistic Target of Rapamycin Complexes (mTORC1/mTORC2) Inhibitors in Pancreatic Beta-Cell Lines (Beta-TC-6)

OBJECTIVES: We investigated the impact of mTOR complexes inhibition with RapaLink-1, a third-generation bivalent mTORC1/mTORC2 inhibitor that links rapamycin with a mTOR-kinase inhibitor, or Torin-2 (ATP-competitive) on mitochondrial dynamics, bioenergetics, and extracellular flux. METHODS: We used...

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Bibliografiske detaljer
Udgivet i:Curr Dev Nutr
Main Authors: Soliman, Ghada, He, Ye
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8181348/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cdn/nzab041_043
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