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Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation

Fibrotic diseases display mesenchymal cell (MC) activation with pathologic deposition of matrix proteins such as collagen. Here we investigate the role of mTOR complex 1 (mTORC1) and mTORC2 in regulating MC collagen expression, a hallmark of fibrotic disease. Relative to normal MCs (non-Fib MCs), MC...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Walker, Natalie M., Belloli, Elizabeth A., Stuckey, Linda, Chan, Kevin M., Lin, Jules, Lynch, William, Chang, Andrew, Mazzoni, Serina M., Fingar, Diane C., Lama, Vibha N.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813558/
https://ncbi.nlm.nih.gov/pubmed/26755732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672170
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