Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation

Fibrotic diseases display mesenchymal cell (MC) activation with pathologic deposition of matrix proteins such as collagen. Here we investigate the role of mTOR complex 1 (mTORC1) and mTORC2 in regulating MC collagen expression, a hallmark of fibrotic disease. Relative to normal MCs (non-Fib MCs), MC...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Walker, Natalie M., Belloli, Elizabeth A., Stuckey, Linda, Chan, Kevin M., Lin, Jules, Lynch, William, Chang, Andrew, Mazzoni, Serina M., Fingar, Diane C., Lama, Vibha N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813558/
https://ncbi.nlm.nih.gov/pubmed/26755732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672170
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